Selank (TP-7 / Selanc)
Also Known AsTP-7 · Selanc · Thr-Lys-Pro-Arg-Pro-Gly-Pro-DAla
Developed at the Institute of Molecular Genetics, Russian Academy of Sciences by Nikolai Myasoedov as a synthetic analog of tuftsin (a naturally occurring immunomodulatory tetrapeptide) with an additional Pro-Gly-Pro sequence for enhanced stability. Approved in Russia as an anxiolytic nasal spray in 2009.
Thr-Lys-Pro-Arg-Pro-Gly-ProHow Selank Works
GABAergic Modulation
Selank modulates the GABA-A receptor system, enhancing GABAergic inhibitory tone without direct receptor binding or benzodiazepine-like dependency. It increases GABA-mediated chloride ion flux, producing anxiolysis without sedation or cognitive impairment.
Monoamine Regulation
Influences serotonin (5-HT) and dopamine metabolism, stabilizing monoamine levels under stress. Gene expression studies show upregulation of genes encoding serotonin transporter, dopamine receptors, and enkephalin — suggesting broad neuromodulatory effects.
BDNF Expression
Upregulates brain-derived neurotrophic factor (BDNF) expression in the hippocampus. BDNF is the primary neurotrophin supporting learning, memory consolidation, and neuroplasticity — this mechanism may underlie the reported nootropic effects.
Immune Modulation (Tuftsin Analog)
As a tuftsin analog, Selank modulates innate immunity by enhancing monocyte/macrophage phagocytic activity and influencing cytokine balance. It normalizes IL-6 and TNF-α levels without immunosuppression, supporting the connection between immune and nervous system regulation.
Published Research
Anxiety & Stress
ModerateRussian clinical trials demonstrated anxiolytic efficacy comparable to benzodiazepines (medazepam) without sedation, cognitive impairment, or dependence. Selank was approved as a nasal spray anxiolytic in Russia in 2009. Gene expression studies show modulation of anxiety-related gene networks in the hippocampus and frontal cortex.
Cognitive Enhancement
ModeratePreclinical and clinical studies demonstrate improved learning, memory consolidation, and attention under stress conditions. Mechanism attributed to BDNF upregulation and stabilization of monoamine balance. Effects are most pronounced under cognitive load and stress, suggesting an adaptogenic rather than pure stimulant profile.
Immunomodulation
ModerateAs a tuftsin-derived peptide, Selank enhances innate immune function without overstimulation. Studies demonstrate increased phagocytic activity, normalized cytokine production, and potential antiviral effects (influenza models). This dual anxiolytic-immunomodulatory profile is unique among peptide therapeutics.
Gene Expression & Neuroscience
EmergingMicroarray studies reveal that Selank modulates expression of 84+ genes in the hippocampus within 1 hour of administration, affecting pathways involved in neurotransmission, apoptosis, inflammation, and cell signaling. This broad transcriptomic effect provides insight into peptide-mediated neuroregulation.
Safety Profile
Selank is approved as a pharmaceutical in Russia (nasal spray) with a well-characterized safety profile from clinical trials. No significant adverse effects, no sedation, no dependence potential, no withdrawal syndrome reported. No lethal dose established in animal studies (extremely high therapeutic index). Compatible with concurrent administration of other nootropics.
Handling & Storage
Reconstitute with bacteriostatic water. Selank is a heptapeptide with good aqueous stability. The Pro-Gly-Pro C-terminal modification provides enhanced resistance to enzymatic degradation. Store reconstituted solution at 2-8°C. Lyophilized powder stable at -20°C.
Peer-Reviewed Literature
- 1
The anxiolytic action of an analog of the endogenous peptide tuftsin on behavior in complex conflict situations
Seredenin SB, Kozlovskaya MM, Blednov YA, et al.
Zhurnal Vysshei Nervnoi Deyatelnosti (Journal of Higher Nervous Activity), 1998 - 2
Immunomodulatory effects of selank in patients with anxiety-asthenic disorders
Uchakina ON, Uchakin PN, Miasoedov NF, et al.
Zhurnal Nevrologii i Psikhiatrii (Journal of Neurology and Psychiatry), 2008PubMed 18833097 - 3
Selank (TKPRPGP) modulation of the expression of genes encoding the elements of GABAergic, glutamatergic, and opioid systems in rat hippocampus
Kasian A, Kolomin T, Andreeva L, et al.
- 4
The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action
Kolomin T, Morozova M, Volkova A, et al.
Selank FAQ
What is Selank?
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed at the Russian Academy of Sciences as a stabilized analog of tuftsin, a naturally occurring immunomodulatory peptide. It was approved in Russia in 2009 as a nasal spray for anxiety and cognitive enhancement, making it one of few peptide-based anxiolytics with regulatory approval.
How does Selank compare to benzodiazepines?
Clinical studies show Selank produces anxiolytic effects comparable to medazepam (a benzodiazepine) without sedation, cognitive impairment, muscle relaxation, or dependence potential. It works through GABA modulation and monoamine stabilization rather than direct benzodiazepine receptor binding, which is why it lacks the classic benzo side effect profile.
What is the difference between Selank and N-Acetyl Selank Amidate?
N-Acetyl Selank Amidate is a modified form with N-terminal acetylation and C-terminal amidation. These modifications further enhance enzymatic stability and membrane permeability compared to standard Selank, potentially improving bioavailability and duration of action in research settings.
Is Selank a nootropic or an anxiolytic?
Both. Selank has a dual profile: it reduces anxiety via GABAergic modulation while simultaneously enhancing cognition via BDNF upregulation and monoamine stabilization. This combination is unusual — most anxiolytics impair cognition. The cognitive benefits are most pronounced under stress conditions, suggesting adaptogenic properties.
Selank Products
All compounds 99%+ purity, verified by Janoshik Analytical. GMP-manufactured lyophilized powder.
Selank
20mgAnxiety gone, brain on — kills anxiety without the fog or sedation of benzos, while simultaneously boosting focus, memory, and cognitive performance.
- Eliminates anxiety without sedation or brain fog
- Enhances focus, memory, and cognitive clarity
Selank 2.0 — the enhanced, stabilized form that lasts longer, absorbs better, and delivers even stronger anxiety relief and cognitive enhancement than the original.
- Enhanced version of Selank — more stable, longer-lasting
- Superior anxiety relief without sedation or cognitive dulling
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Selank 2.0 — the enhanced, stabilized form that lasts longer, absorbs better, and delivers even stronger anxiety relief and cognitive enhancement than the original.
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- Superior anxiety relief without sedation or cognitive dulling
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Disclaimer: This monograph is provided for educational and research purposes only. G26x Peptides products are sold exclusively as research chemicals. They are not intended for human consumption, therapeutic use, or as dietary supplements. All research should be conducted in compliance with applicable laws and institutional review board protocols. Information presented here is sourced from published peer-reviewed literature and does not constitute medical advice.